2008 Pre-Season
 | Friday, August 8 | at Oakland | 7p.m. |
 | Saturday, August 16 | vs. Green Bay | 6p.m. |
 | Thursday, August 21 | @ Chicago | 5 p.m. |
 | Friday, August 29 | vs. San Diego | 7p.m. |
2008 Regular Season
 | September 7 | vs. Arizona | 1:15 p.m. |
 | September 14 | @ Seattle | 1:05 p.m. |
 | September 21 | Detroit | 1:05 p.m. |
 | September 28 | at New Orleans | 10 a.m. |
 | October 5 | vs. New England | 1:15 p.m. |
 | October 12 | Philadelphia | 1:15 p.m. |
 | October 19 | @ N.Y. Giants | 10 a.m. |
| October 26 | vs. Seattle | 1:15 p.m. |
| November 2 | BYE | ||
| November 10# | @ Arizona | 5:30 p.m. |
 | November 16* | vs. St. Louis | 1:05 p.m. |
 | November 23* | @ Dallas | 10 a.m. |
 | November 30* | @ Buffalo | 10 a.m. |
 | December 7* | vs. N.Y. Jets | 1:05 p.m. |
 | December 14* | @ Miami | 10 a.m. |
| December 21* | @ St. Louis | 10 a.m. |
 | December 28* | Washington | 1:15 p.m. |
# Indicates Monday Night Football
All Times are PST
*Please be aware that as part of the National Football League’s agreement with NBC to televise Sunday Night Football, the NFL has implemented a flexible schedule for Sunday start times for the final seven weeks of the season.
This will allow the NFL to bring more attractive match-ups to a national audience late in the season. If any of the 49ers games are moved from the original start time, fans will be notified 12 days prior to the date of the game with the exception of a Week 17 game, where the notification will be six days to ensure a Sunday Night game with playoff implications. Starting time changes will be publicized on 49ers.com and through the local print, electronic and internet media.
